2. Immunology/Inflammation
  3. Interleukin Related
  4. Ustekinumab

Ustekinumab  (Synonyms: Anti-Human IL-12/IL-23, Human Antibody)

Cat. No.: HY-P9909 Purity: 98.42%
COA

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Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

For research use only. We do not sell to patients.

Ustekinumab Chemical Structure

Ustekinumab Chemical Structure

CAS No. : 815610-63-0

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Based on 1 publication(s) in Google Scholar

Ustekinumab Related Antibodies

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Description

Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

IC50 & Target

IL-12

 

IL-23

 

In Vitro

Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells[1]. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (KD) is calculated relative to Ustekinumab (Ustekinumab=1.0)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ustekinumab Related Antibodies
Clinical Trial
Molecular Weight

145625.97

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ustekinumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.42%

COA (292 KB)

Handling Instructions (2659 KB)
References
Cell Assay
[2]

HUVECs are grown on calibrated glass coverslips to a confluency of 80%. Subsequently, cells are incubated with 200 µg/mL Ustekinumab AlexaFluor488 and Briakinumab AlexaFluor594 for 20 min at 37°C, pH 7.3, washed three times, and chased in fresh medium for an additional 20 min before fixation. Antibodies are directly labeled. FcRn binding is quality controlled by SPR analysis. Cells are then counterstained with anti-FcRn monoclonal antibody DVN22, followed by anti-mouse secondary antibodies conjugated to AlexaFluor647. Imaging is performed on a Leica SP8 confocal microscope[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Ustekinumab Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ustekinumab815610-63-0Anti-Human IL-12/IL-23, Human AntibodyInterleukin RelatedILInhibitorinhibitorinhibit

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