2. Metabolic Enzyme/Protease Apoptosis
  3. Farnesyl Transferase Apoptosis
  4. ABT-100

ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity.

For research use only. We do not sell to patients.

ABT-100 Chemical Structure

ABT-100 Chemical Structure

CAS No. : 450839-40-4

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1 mg USD 100 In-stock
5 mg USD 360 In-stock
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Based on 1 publication(s) in Google Scholar

ABT-100 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity[1].

IC50 & Target

Farnesyltransferase[1]
In Vitro

ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. Also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABT-100 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells
Concentration: 0.1-100 nM
Incubation Time: 7 days
Result: Demonstrated dose-dependent growth inhibition of human cancer cell lines.
In Vivo

ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C.B-17 scid male mice with EJ-1 cells[1]
Dosage: 6.25 mg/kg/day, 12.5 mg/kg/day
Administration: Subcutaneous injection; daily; for 21 days
Result: Regressed EJ-1 tumors in C.B-17 scid male mice.
Molecular Weight

504.46

Formula

C27H19F3N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC(C2=CC=C(OC(F)(F)F)C=C2)=C(OC[C@](O)(C3=CC=C(C#N)C=C3)C4=CN=CN4C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (99.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9823 mL 9.9116 mL 19.8232 mL
5 mM 0.3965 mL 1.9823 mL 3.9646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.18%

COA (252 KB) HNMR (111 KB) RP-HPLC (131 KB) MS (119 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9823 mL 9.9116 mL 19.8232 mL 49.5579 mL
5 mM 0.3965 mL 1.9823 mL 3.9646 mL 9.9116 mL
10 mM 0.1982 mL 0.9912 mL 1.9823 mL 4.9558 mL
15 mM 0.1322 mL 0.6608 mL 1.3215 mL 3.3039 mL
20 mM 0.0991 mL 0.4956 mL 0.9912 mL 2.4779 mL
25 mM 0.0793 mL 0.3965 mL 0.7929 mL 1.9823 mL
30 mM 0.0661 mL 0.3304 mL 0.6608 mL 1.6519 mL
40 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2389 mL
50 mM 0.0396 mL 0.1982 mL 0.3965 mL 0.9912 mL
60 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8260 mL
80 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6195 mL
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ABT-100 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-100450839-40-4ABT100ABT 100Farnesyl TransferaseApoptosisFtaseAntitumorfarnesyltransferaseantiproliferationregressesapoptosisangiogenesisorallyInhibitorinhibitorinhibit

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