2',3'-cGMP sodium (Synonyms: Guanosine 2',3'-cyclic monophosphate sodium salt)

Cat. No.: HY-N8245 Purity: 99.28%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase.

For research use only. We do not sell to patients.

2',3'-cGMP sodium Chemical Structure

CAS No. : 15718-49-7

Size	Price	Stock	Quantity
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2700	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Other Forms of 2',3'-cGMP sodium:

2′,3′-cGMP triethylamine Get quote

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Biological Activity
Purity & Documentation
References
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Description

2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase^[1].

In Vitro

2',3'-cGMP sodium (10 nM-100 μM, 120 min) reduces the active transport of [³H]3’,5’-cGMP into inside-out vesicles from human erythrocytes^[2].
2',3'-cGMP sodium (2 μM) increases the ATPase activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.19

Formula

C₁₀H₁₁N₅NaO₇P

CAS No.

15718-49-7

Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]1O[C@](N2C3=C(C(N=C(N3)N)=O)N=C2)([H])[C@@]4([H])[C@]1([H])OP(O4)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (272.34 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7234 mL	13.6169 mL	27.2339 mL
5 mM	0.5447 mL	2.7234 mL	5.4468 mL
10 mM	0.2723 mL	1.3617 mL	2.7234 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.28%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (256 KB) HNMR (241 KB) CNMR (274 KB) RP-HPLC (197 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Sokurenko JV, et al. [Identification of 2',3'-cGMP as an intermediate of RNA catalytic cleavage by binase and evaluation of its biological action]. Bioorg Khim. 2015 Jan-Feb;41(1):37-43. Russian. [Content Brief]

[2]. Boadu E, et al. Inhibition by guanosine cyclic monophosphate (cGMP) analogues of uptake of [(3)H]3',5'-cGMP without stimulation of ATPase activity in human erythrocyte inside-out vesicles. Biochem Pharmacol. 2001 Aug 15;62(4):425-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.7234 mL	13.6169 mL	27.2339 mL	68.0846 mL
	5 mM	0.5447 mL	2.7234 mL	5.4468 mL	13.6169 mL
	10 mM	0.2723 mL	1.3617 mL	2.7234 mL	6.8085 mL
	15 mM	0.1816 mL	0.9078 mL	1.8156 mL	4.5390 mL
	20 mM	0.1362 mL	0.6808 mL	1.3617 mL	3.4042 mL
	25 mM	0.1089 mL	0.5447 mL	1.0894 mL	2.7234 mL
	30 mM	0.0908 mL	0.4539 mL	0.9078 mL	2.2695 mL
	40 mM	0.0681 mL	0.3404 mL	0.6808 mL	1.7021 mL
	50 mM	0.0545 mL	0.2723 mL	0.5447 mL	1.3617 mL
	60 mM	0.0454 mL	0.2269 mL	0.4539 mL	1.1347 mL
	80 mM	0.0340 mL	0.1702 mL	0.3404 mL	0.8511 mL
	100 mM	0.0272 mL	0.1362 mL	0.2723 mL	0.6808 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

2',3'-cGMP sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2',3'-cGMP15718-49-7Guanosine 2',3'-cyclic monophosphateOtherscGMPRNA catalytic cleavagebinaseInhibitorinhibitorinhibit

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