2. Anti-infection
  3. Fungal
  4. Hydroxy Itraconazole-d8

Hydroxy Itraconazole-d8  (Synonyms: R-63373-d8)

Cat. No.: HY-12772S Purity: 99.71%
COA Handling Instructions

Molarity Calculator

Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

For research use only. We do not sell to patients.

Hydroxy Itraconazole-d<sub>8</sub> Chemical Structure

Hydroxy Itraconazole-d8 Chemical Structure

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1 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Hydroxy Itraconazole-d8:

Hydroxy Itraconazole-d8 Related Antibodies

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Description

Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

Molecular Weight

729.68

Formula

C35H30D8Cl2N8O5
Unlabeled CAS

112559-91-8
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(C([2H])([2H])[2H])([2H])C(O)([2H])C([2H])([2H])[2H])N=CN1C2=CC=C(N3CCN(C4=CC=C(OCC5OC(CN6N=CN=C6)(C7=CC=C(Cl)C=C7Cl)OC5)C=C4)CC3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (114.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (1.37 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3705 mL 6.8523 mL 13.7046 mL
5 mM 0.2741 mL 1.3705 mL 2.7409 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.71%

COA (249 KB) LCMS (121 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.3705 mL 6.8523 mL 13.7046 mL 34.2616 mL
DMSO 5 mM 0.2741 mL 1.3705 mL 2.7409 mL 6.8523 mL
10 mM 0.1370 mL 0.6852 mL 1.3705 mL 3.4262 mL
15 mM 0.0914 mL 0.4568 mL 0.9136 mL 2.2841 mL
20 mM 0.0685 mL 0.3426 mL 0.6852 mL 1.7131 mL
25 mM 0.0548 mL 0.2741 mL 0.5482 mL 1.3705 mL
30 mM 0.0457 mL 0.2284 mL 0.4568 mL 1.1421 mL
40 mM 0.0343 mL 0.1713 mL 0.3426 mL 0.8565 mL
50 mM 0.0274 mL 0.1370 mL 0.2741 mL 0.6852 mL
60 mM 0.0228 mL 0.1142 mL 0.2284 mL 0.5710 mL
80 mM 0.0171 mL 0.0857 mL 0.1713 mL 0.4283 mL
100 mM 0.0137 mL 0.0685 mL 0.1370 mL 0.3426 mL
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Hydroxy Itraconazole-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxy Itraconazole-d8R-63373-d8FungalInhibitorinhibitorinhibit

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