2. Immunology/Inflammation
  3. COX
  4. Propyphenazone

Propyphenazone  (Synonyms: 4-Isopropylantipyrine; Isopropylphenazone)

Cat. No.: HY-A0273 Purity: 99.94%
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Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity.

For research use only. We do not sell to patients.

Propyphenazone Chemical Structure

Propyphenazone Chemical Structure

CAS No. : 479-92-5

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Other Forms of Propyphenazone:

Propyphenazone Related Antibodies

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Description

Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity[1][2].

IC50 & Target[1]

COX

 

In Vivo

Propyphenazone (4-Isopropylantipyrine; 0.7, 7, 70 mg/kg; oral gavage; the entire second week of gestation, days 8-14 of gestation), administered Propyphenazone:Caffeine and Propyphenazone:Paracetamol mixtures with constant 3:1 and 3:5 ratios, causes intrauterine growth retardation but does not increase external or internal congenital anomalies in pregnant Wistar rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

230.31

Formula

C14H18N2O
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 2.6 mg/mL (11.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3420 mL 21.7099 mL 43.4197 mL
5 mM 0.8684 mL 4.3420 mL 8.6839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3420 mL 21.7099 mL 43.4197 mL 108.5493 mL
5 mM 0.8684 mL 4.3420 mL 8.6839 mL 21.7099 mL
10 mM 0.4342 mL 2.1710 mL 4.3420 mL 10.8549 mL
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Propyphenazone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propyphenazone479-92-54-Isopropylantipyrine IsopropylphenazoneCOXCyclooxygenasePyrazolenonsteroidal anti-inflammatory drugNSAIDreducing painanti-inflammatoryanalgesicInhibitorinhibitorinhibit

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