Aldose Reductase

Related Products

Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney.

Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it.

Aldose Reductase Inhibitors (60)

Aldose Reductase Related Products (64)
Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0102

Isoliquiritigenin	Inhibitor	98.02%
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC₅₀ of 24.7 μM.

HY-66009

Epalrestat	Inhibitor	99.72%
Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy.

HY-N0033

Poliumoside	Inhibitor	99.80%
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity.

HY-105185

Fidarestat	Inhibitor	99.63%
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC₅₀s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

HY-N0310

Soyasaponin Bb	Inhibitor	99.13%
soyasaponin Bb is a soyasaponin isolated from Phaseolus vulgaris, acting as an aldose reductase differential inhibitor (ARDI).

HY-16500R

Tolrestat (Standard)	Inhibitor
Tolrestat (Standard) is the analytical standard of Tolrestat. This product is intended for research and analytical applications. Tolrestat is a potent, orally active aldose reductase inhibitor with IC₅₀ of 35 nM.

HY-163610

AKR1C3-IN-13	Inhibitor
AKR1C3-IN-13 (Compound 4) is an AKR1C3 inhibitor. AKR1C3-IN-13 degrades AKR1C3 in prostate cancer cells.

HY-N12862

Floramanoside A	Inhibitor
Floramanoside A is a flavonol glycoside that can be isolated from the flowers of Abelmouschus manihot. Floramanoside A has DPPH scavenging (IC₅₀: 10.1 μM) and aldose reductase inhibition activities (IC₅₀: 17.8 μM).

HY-16500

Tolrestat	Inhibitor	99.37%
Tolrestat is a potent, orally active aldose reductase inhibitor with IC₅₀ of 35 nM.

HY-106697

Ponalrestat	Inhibitor	99.71%
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (K_i=7.7 nM) over ALR1 (K_i=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol.

HY-50289

Sorbinil	Inhibitor	99.85%
Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.

HY-N0539

Calceolarioside B		99.93%
Calceolarioside B is a natural product isolated from Akebia quinata leaves. Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC₅₀ of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC₅₀ of 94.60 μM .

HY-16255

Imirestat	Inhibitor	99.86%
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

HY-18967

Caficrestat	Inhibitor	99.74%
Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC₅₀ of 28.9 pM.

HY-B1202

Alrestatin	Inhibitor	99.67%
Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

HY-13633

Exisulind	Inhibitor	98.03%
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. Exisulind inhibits aldose reductase with an IC₅₀ of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications.

HY-N1517

Ganoderic acid C2		99.30%
Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (RLAR) with an IC₅₀ of 3.8 µM.

HY-N4089

Quercetin 3-gentiobioside	Inhibitor	99.92%
Quercetin 3-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs).

HY-133708

β-Glucogallin	Inhibitor	99.82%
β-Glucogallin is a potent and selective aldose reductase (AKR1B1) inhibitor. β-Glucogallin can be isolated from the medicinal plant Emblica officinalis.

HY-19687

Zopolrestat	Inhibitor	99.94%
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC₅₀ of 3.1 nM. Zopolrestat is used for the research of diabetic complications.

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Aldose Reductase

Aldose Reductase

Aldose Reductase Related Products (64)

Antibodies (1)

Aldose Reductase Related Products (64):