Urotensin II, mouse 

Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system^[1].

GPR14^[1]

This sequence of the C-terminus cyclic region of Urotensin II (U-II) is completely conserved in most species, including in the fish, frog, human, porcine, rat, and mouse, and it is thought to be essential for the agonistic activity of U-II. Urotensin II plays a physiological role in the central nervous system. Intracerebroventricular administration of Urotensin II induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner, as do corticotropin releasing factor (CRF). The effective doses of Urotensin II are 10-100-fold higher than these of CRF in these tests^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Urotensin II is a somatostatin-like cyclic peptide which functions as an arterial vasocontrictor, vasodilator, and bronchoconstriction mediator^[1].
Urotensin II (0.1 nmol, 0.3 nmol, and 3 nmol; intracerebroventricular administration) induces anxiogenic-like behaviors in the elevated plus maze test and the hole-board test in mice in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1633.85

C₇₆H₁₀₀N₁₈O₁₉S₂

405137-01-1

{pGlu}-His-Gly-Ala-Ala-Pro-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Ile (Disulfide bridge: Cys8-Cys13)

{pGlu}-HGAAPECFWKYCI (Disulfide bridge: Cys8-Cys13)

O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCCN)=O)CC2=CC=C(C=C2)O)=O)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)NC([C@H](CCC(O)=O)NC([C@H]3N(CCC3)C([C@H](C)NC([C@H](C)NC(CNC([C@@H](NC([C@@H]4CCC(N4)=O)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)=O)CC6=CC=CC=C6)N[C@H]1CC7=CNC8=CC=CC=C78

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• [1]. Matsumoto Y, et al. Intracerebroventricular administration of urotensin II promotes anxiogenic-like behaviors in rodents. Neurosci Lett. 2004 Mar 25;358(2):99-102.  [Content Brief]