2. Apoptosis
  3. Bcl-2 Family
  4. ABBV-467

ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma.

For research use only. We do not sell to patients.

ABBV-467 Chemical Structure

ABBV-467 Chemical Structure

CAS No. : 2287186-66-5

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1 mg USD 190 In-stock
5 mg USD 480 In-stock
10 mg USD 780 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].

IC50 & Target

MCL-1[1].
Molecular Weight

1037.98

Formula

C53H51Cl2FN6O9S
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)[C@@H](CC1=CC2=CC=C1OCC3=NC(C4=CC=C(OC[C@H]5OCCOC5)C=C4)=NC=C3)OC6=NC=NC7=C6C(C8=C(C)C(Cl)=C(O[C@@H](CO2)CN9CCN(C)CC9)C(Cl)=C8C)=C(C%10=CC=C(F)C=C%10)S7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (120.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9634 mL 4.8170 mL 9.6341 mL
5 mM 0.1927 mL 0.9634 mL 1.9268 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9634 mL 4.8170 mL 9.6341 mL 24.0852 mL
5 mM 0.1927 mL 0.9634 mL 1.9268 mL 4.8170 mL
10 mM 0.0963 mL 0.4817 mL 0.9634 mL 2.4085 mL
15 mM 0.0642 mL 0.3211 mL 0.6423 mL 1.6057 mL
20 mM 0.0482 mL 0.2409 mL 0.4817 mL 1.2043 mL
25 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9634 mL
30 mM 0.0321 mL 0.1606 mL 0.3211 mL 0.8028 mL
40 mM 0.0241 mL 0.1204 mL 0.2409 mL 0.6021 mL
50 mM 0.0193 mL 0.0963 mL 0.1927 mL 0.4817 mL
60 mM 0.0161 mL 0.0803 mL 0.1606 mL 0.4014 mL
80 mM 0.0120 mL 0.0602 mL 0.1204 mL 0.3011 mL
100 mM 0.0096 mL 0.0482 mL 0.0963 mL 0.2409 mL
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ABBV-467 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABBV-4672287186-66-5ABBV467ABBV 467Bcl-2 FamilyAMO-1 xenograftOPM-2 xenograftcancermultiple myelomatumorInhibitorinhibitorinhibit

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