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  3. Biochemical Assay Reagents
  4. ABT-737-d8

ABT 737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.

For research use only. We do not sell to patients.

ABT-737-d<sub>8</sub> Chemical Structure

ABT-737-d8 Chemical Structure

CAS No. : 1217686-68-4

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1 mg USD 740 In-stock
5 mg USD 1850 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of ABT-737-d8:

ABT-737-d8 Related Antibodies

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Description

ABT 737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABT-737-d8 Related Antibodies
Molecular Weight

821.48

Formula

C42H37D8ClN6O5S2
CAS No.
Unlabeled Cas

852808-04-9
Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC(C=C1)=CC=C1C(C=CC=C2)=C2CN3C([2H])([2H])C([2H])([2H])N(C4=CC=C(C=C4)C(NS(=O)(C5=CC([N+]([O-])=O)=C(C=C5)N[C@H](CCN(C)C)CSC6=CC=CC=C6)=O)=O)C([2H])([2H])C3([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (60.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2173 mL 6.0866 mL 12.1732 mL
5 mM 0.2435 mL 1.2173 mL 2.4346 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2173 mL 6.0866 mL 12.1732 mL 30.4329 mL
5 mM 0.2435 mL 1.2173 mL 2.4346 mL 6.0866 mL
10 mM 0.1217 mL 0.6087 mL 1.2173 mL 3.0433 mL
15 mM 0.0812 mL 0.4058 mL 0.8115 mL 2.0289 mL
20 mM 0.0609 mL 0.3043 mL 0.6087 mL 1.5216 mL
25 mM 0.0487 mL 0.2435 mL 0.4869 mL 1.2173 mL
30 mM 0.0406 mL 0.2029 mL 0.4058 mL 1.0144 mL
40 mM 0.0304 mL 0.1522 mL 0.3043 mL 0.7608 mL
50 mM 0.0243 mL 0.1217 mL 0.2435 mL 0.6087 mL
60 mM 0.0203 mL 0.1014 mL 0.2029 mL 0.5072 mL
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ABT-737-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-737-d81217686-68-4Biochemical Assay ReagentsInhibitorinhibitorinhibit

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