2. PROTAC
  3. PROTAC Linkers
  4. Acid-C1-PEG5-Boc

Acid-C1-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Acid-C1-PEG5-Boc Chemical Structure

Acid-C1-PEG5-Boc Chemical Structure

CAS No. : 2304558-22-1

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2 mg USD 112 In-stock
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Based on 1 publication(s) in Google Scholar

Acid-C1-PEG5-Boc Related Antibodies

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Description

Acid-C1-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acid-C1-PEG5-Boc Related Antibodies
Molecular Weight

380.43

Formula

C17H32O9
CAS No.
Unlabeled CAS

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (328.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6286 mL 13.1430 mL 26.2860 mL
5 mM 0.5257 mL 2.6286 mL 5.2572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6286 mL 13.1430 mL 26.2860 mL 65.7151 mL
5 mM 0.5257 mL 2.6286 mL 5.2572 mL 13.1430 mL
10 mM 0.2629 mL 1.3143 mL 2.6286 mL 6.5715 mL
15 mM 0.1752 mL 0.8762 mL 1.7524 mL 4.3810 mL
20 mM 0.1314 mL 0.6572 mL 1.3143 mL 3.2858 mL
25 mM 0.1051 mL 0.5257 mL 1.0514 mL 2.6286 mL
30 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1905 mL
40 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.6429 mL
50 mM 0.0526 mL 0.2629 mL 0.5257 mL 1.3143 mL
60 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
80 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8214 mL
100 mM 0.0263 mL 0.1314 mL 0.2629 mL 0.6572 mL
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Acid-C1-PEG5-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acid-C1-PEG5-Boc2304558-22-1PROTAC LinkersInhibitorinhibitorinhibit

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