2. Neuronal Signaling Immunology/Inflammation GPCR/G Protein Membrane Transporter/Ion Channel Protein Tyrosine Kinase/RTK
  3. Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor
  4. Amitriptyline-d6 hydrochloride

Amitriptyline-d6 hydrochloride 

Cat. No.: HY-B0527AS Purity: 99.65%
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Amitriptyline-d6 (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

For research use only. We do not sell to patients.

Amitriptyline-d<sub>6</sub> hydrochloride Chemical Structure

Amitriptyline-d6 hydrochloride Chemical Structure

CAS No. : 203645-63-0

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5 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Amitriptyline-d6 hydrochloride:

Amitriptyline-d6 hydrochloride Related Antibodies

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Description

Amitriptyline-d6 (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amitriptyline-d6 hydrochloride Related Antibodies
Molecular Weight

319.90

Formula

C20H18D6ClN
CAS No.
Unlabeled Cas

549-18-8
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CC/C=C1C2=CC=CC=C2CCC3=CC=CC=C3/1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (312.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (156.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1260 mL 15.6299 mL 31.2598 mL
5 mM 0.6252 mL 3.1260 mL 6.2520 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.1260 mL 15.6299 mL 31.2598 mL 78.1494 mL
5 mM 0.6252 mL 3.1260 mL 6.2520 mL 15.6299 mL
10 mM 0.3126 mL 1.5630 mL 3.1260 mL 7.8149 mL
15 mM 0.2084 mL 1.0420 mL 2.0840 mL 5.2100 mL
20 mM 0.1563 mL 0.7815 mL 1.5630 mL 3.9075 mL
25 mM 0.1250 mL 0.6252 mL 1.2504 mL 3.1260 mL
30 mM 0.1042 mL 0.5210 mL 1.0420 mL 2.6050 mL
40 mM 0.0781 mL 0.3907 mL 0.7815 mL 1.9537 mL
50 mM 0.0625 mL 0.3126 mL 0.6252 mL 1.5630 mL
60 mM 0.0521 mL 0.2605 mL 0.5210 mL 1.3025 mL
80 mM 0.0391 mL 0.1954 mL 0.3907 mL 0.9769 mL
100 mM 0.0313 mL 0.1563 mL 0.3126 mL 0.7815 mL
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Amitriptyline-d6 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amitriptyline-d6203645-63-0Serotonin Transporter5-HT ReceptorHistamine ReceptormAChRAdrenergic ReceptorSodium ChannelTrk Receptor5-HTTSERTSLC6A4Serotonin Receptor5-hydroxytryptamine ReceptorMuscarinic acetylcholine receptorBeta ReceptorNa channelsNa+ channelsTropomyosin related kinase receptorInhibitorinhibitorinhibit

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