Azithromycin-d₃

Cat. No.: HY-17506S: FAQs
Data Sheet SDS COA Handling Instructions

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Azithromycin-d₃ is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections[1][2].

For research use only. We do not sell to patients.

Azithromycin-d<sub>3</sub> Chemical Structure

Azithromycin-d₃ Chemical Structure

CAS No. : 163921-65-1

Size	Price	Stock
1 mg	USD 270	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Azithromycin-d₃:

Azithromycin In-stock
Azithromycin hydrate In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Azithromycin-d₃ is the deuterium labeled Azithromycin. Azithromycin (CP-62993) is a macrolide antibiotic useful for the treatment of a number of bacterial infections[1][2].

IC₅₀ & Target

Macrolide

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

752.00

Formula

C₃₈H₆₉D₃N₂O₁₂

CAS No.

163921-65-1

Unlabeled Cas

83905-01-5

Appearance

Solid

Color

White to light yellow

SMILES

C[C@H]([C@@H](O[C@@]([H])([C@@H]1O)O[C@@H](C[C@@H]1N(C)C)C)[C@](C[C@@H](C)CN2C([2H])([2H])[2H])(C)O)[C@H](O[C@@]([H])(C[C@]3(OC)C)O[C@H]([C@@H]3O)C)[C@@H](C)C(O[C@@H]([C@@](O)([C@@H]([C@H]2C)O)C)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (132.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 100 mg/mL (132.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3298 mL	6.6489 mL	13.2979 mL
5 mM	0.2660 mL	1.3298 mL	2.6596 mL
10 mM	0.1330 mL	0.6649 mL	1.3298 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (283 KB) SDS (251 KB)

COA (267 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18. [Content Brief]

[3]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	1.3298 mL	6.6489 mL	13.2979 mL	33.2447 mL
	5 mM	0.2660 mL	1.3298 mL	2.6596 mL	6.6489 mL
	10 mM	0.1330 mL	0.6649 mL	1.3298 mL	3.3245 mL
	15 mM	0.0887 mL	0.4433 mL	0.8865 mL	2.2163 mL
	20 mM	0.0665 mL	0.3324 mL	0.6649 mL	1.6622 mL
	25 mM	0.0532 mL	0.2660 mL	0.5319 mL	1.3298 mL
	30 mM	0.0443 mL	0.2216 mL	0.4433 mL	1.1082 mL
	40 mM	0.0332 mL	0.1662 mL	0.3324 mL	0.8311 mL
	50 mM	0.0266 mL	0.1330 mL	0.2660 mL	0.6649 mL
	60 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5541 mL
	80 mM	0.0166 mL	0.0831 mL	0.1662 mL	0.4156 mL
	100 mM	0.0133 mL	0.0665 mL	0.1330 mL	0.3324 mL