1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Definition:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate.

References:

[1]. H F Cheng, et al. Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. J Biol Chem. 1995 Mar 10;270(10):5495-505. [Content Brief]

[2]. E Tall, et al. Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs. Biochemistry. 1997 Jun 10;36(23):7239-48. [Content Brief]

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