2-acylglycerol O-acyltransferase 2

Definition:

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG).

References:

[1]. Chi-Liang Eric Yen, et al. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J Biol Chem. 2003 May 16;278(20):18532-7. [Content Brief]

[2]. Zhengping Ma, et al. Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases. J Lipid Res. 2017 Jun;58(6):1091-1099. [Content Brief]

[3]. Curtis Brandt, et al. Biochemical characterization of human acyl coenzyme A: 2-monoacylglycerol acyltransferase-3 (MGAT3). Biochem Biophys Res Commun. 2016 Jul 1;475(3):264-70. [Content Brief]

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