2-hydroxyacyl-CoA lyase 2

Definition:

Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway.

References:

[1]. Takuya Kitamura, et al. Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2616-E2623. [Content Brief]

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