5-aminolevulinate synthase, non-specific, mitochondrial

Definition:

Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products.

References:

[1]. Anne-Kathrin Peyer, et al. Regulation of human liver delta-aminolevulinic acid synthase by bile acids. Hepatology. 2007 Dec;46(6):1960-70. [Content Brief]

[2]. Mohamed Abu-Farha, et al. Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition. Biochem Cell Biol. 2005 Oct;83(5):620-30. [Content Brief]

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