DNA damage-regulated autophagy modulator protein 1

Definition:

Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.

References:

[1]. Diane Crighton, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell. 2006 Jul 14;126(1):121-34. [Content Brief]

[2]. D Crighton, et al. p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ. 2007 Jun;14(6):1071-9. [Content Brief]

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