PAN2-PAN3 deadenylation complex catalytic subunit PAN2

Definition:

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.

References:

[1]. John S Bett, et al. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Biochem J. 2013 Apr 15;451(2):185-94. [Content Brief]

[2]. Akio Yamashita, et al. Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover. Nat Struct Mol Biol. 2005 Dec;12(12):1054-63. [Content Brief]

[3]. Naoyuki Uchida, et al. Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. J Biol Chem. 2004 Jan 9;279(2):1383-91. [Content Brief]

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