Paraplegin

Definition:

ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function.

References:

[1]. Santhanam Shanmughapriya, et al. SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. Mol Cell. 2015 Oct 1;60(1):47-62. [Content Brief]

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