Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Definition:

Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.

References:

[1]. Diana G Wang, et al. PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell Rep. 2019 May 14;27(7):1991-2001.e5. [Content Brief]

[2]. Kazutaka Sumita, et al. The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. Mol Cell. 2016 Jan 21;61(2):187-98. [Content Brief]

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