PIH1 domain-containing protein 1

Definition:

Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.

References:

[1]. Yuya Kamano, et al. PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. FEBS Lett. 2013 Oct 11;587(20):3303-8. [Content Brief]

[2]. Kenneth Scott McKeegan, et al. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. Mol Cell Biol. 2007 Oct;27(19):6782-93. [Content Brief]

[3]. Zuzana Horejsí, et al. CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability. Mol Cell. 2010 Sep 24;39(6):839-50. [Content Brief]

[4]. Niu Zhai, et al. Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis. J Mol Cell Biol. 2012 Aug;4(4):231-41. [Content Brief]

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