Pleckstrin homology-like domain family A member 3

Definition:

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

References:

[1]. Tatsuya Kawase, et al. PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell. 2009 Feb 6;136(3):535-50. [Content Brief]

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