Pore-forming toxins (PFTs)

Definition:

Pore-forming toxins (PFTs) are water-soluble molecules that have been identified as the most crucial virulence factors during bacterial pathogenesis. PFTs disrupt the host cell membrane to internalize or to deliver other bacterial or virulence factors for establishing infections. Disruption of the host cell membrane by PFTs can lead to uncontrollable exchanges between the extracellular and the intracellular matrix, thereby disturbing the cellular homeostasis.

References:

[1]. Banerji R, et al. Pore-forming toxins of foodborne pathogens. Compr Rev Food Sci Food Saf. 2021 May;20(3):2265-2285. [Content Brief]

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