Potassium voltage-gated channel subfamily V member 1

Definition:

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

References:

[1]. M Salinas, et al. Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. J Biol Chem. 1997 Mar 28;272(13):8774-80. [Content Brief]

[2]. J P Hugnot, et al. Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J. 1996 Jul 1;15(13):3322-31. [Content Brief]

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