Primary amoebic meningoencephalitis (PAM)

Definition:

Primary amoebic meningoencephalitis (PAM) is a perilous and devastating waterborne disease caused by Naegleria fowleri. N. fowleri is a free-living, thermophilic amoeba distributed worldwide in soil and warm freshwater. PAM is a rare but fatal disease usually affecting children and young adults all around the world. This acute infection is developed by the entry of N. fowleri through nasal cavity.

References:

[1]. Eddie Grace, et al. Naegleria fowleri: pathogenesis, diagnosis, and treatment options. Antimicrob Agents Chemother. 2015 Nov;59(11):6677-81. [Content Brief]

[2]. Gentle Sunder Shrestha, et al. Primary amoebic meningoencephalitis. J Neurosci Rural Pract. 2015 Apr-Jun;6(2):284-6. [Content Brief]

[3]. Muhammad Jahangeer, et al. Naegleria fowleri: Sources of infection, pathophysiology, diagnosis, and management; a review. Clin Exp Pharmacol Physiol. 2020 Feb;47(2):199-212. [Content Brief]

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