Prolow-density lipoprotein receptor-related protein 1

Definition:

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.; (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

References:

[1]. Petra May, et al. LDL receptor-related proteins in neurodevelopment. Traffic. 2003 May;4(5):291-301. [Content Brief]

[2]. Jennifer N Rauch, et al. LRP1 is a master regulator of tau uptake and spread. Nature. 2020 Apr;580(7803):381-385. [Content Brief]

[3]. Joakim Klar, et al. Whole exome sequencing identifies LRP1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans. J Med Genet. 2015 Sep;52(9):599-606. [Content Brief]

[4]. T Kristensen, et al. Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor. FEBS Lett. 1990 Dec 10;276(1-2):151-5. [Content Brief]

[5]. Petra May, et al. Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem. 2002 May 24;277(21):18736-43. [Content Brief]

[6]. M Z Kounnas, et al. The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J Biol Chem. 1992 Jun 25;267(18):12420-3. [Content Brief]

[7]. Ayae Kinoshita, et al. The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J Biol Chem. 2003 Oct 17;278(42):41182-8. [Content Brief]

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