Prostacyclin synthase

Definition:

Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE).

References:

[1]. Masayuki Wada, et al. Purification and characterization of recombinant human prostacyclin synthase. J Biochem. 2004 Apr;135(4):455-63. [Content Brief]

[2]. Tomohiro Nakayama, et al. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Biochem Biophys Res Commun. 2002 Oct 11;297(5):1135-9. [Content Brief]

[3]. Hui-Chun Yeh, et al. Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. Arch Biochem Biophys. 2007 May 15;461(2):159-68. [Content Brief]

[4]. Yi-Ching Li, et al. Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change. J Biol Chem. 2008 Feb 1;283(5):2917-26. [Content Brief]

[5]. Sun-Ah Cho, et al. Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans. Arch Biochem Biophys. 2015 Mar 1;569:10-8. [Content Brief]

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