Proteasomal ubiquitin receptor ADRM1

Definition:

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.

References:

[1]. Lianying Jiao, et al. Mechanism of the Rpn13-induced activation of Uch37. Protein Cell. 2014;5(8):616-30. [Content Brief]

[2]. Koraljka Husnjak, et al. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature. 2008 May 22;453(7194):481-8. [Content Brief]

[3]. Danny D Sahtoe, et al. Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. Mol Cell. 2015 Mar 5;57(5):887-900. [Content Brief]

[4]. Ryan T Vander Linden, et al. Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Mol Cell. 2015 Mar 5;57(5):901-911. [Content Brief]

[5]. Tingting Yao, et al. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol. 2006 Sep;8(9):994-1002. [Content Brief]

[6]. Xiao-Bo Qiu, et al. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 2006 Dec 13;25(24):5742-53. [Content Brief]

[7]. Jun Hamazaki, et al. A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J. 2006 Oct 4;25(19):4524-36. [Content Brief]

[8]. Jakob Ploug Jørgensen, et al. Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor. J Mol Biol. 2006 Jul 28;360(5):1043-52. [Content Brief]

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