Protein BEX4

Definition:

May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability.

References:

[1]. Jin-Kwan Lee, et al. Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition. Cell Death Dis. 2016 Aug 11;7(8):e2336. [Content Brief]

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