Protein BRAWNIN

Definition:

Essential for mitochondrial respiratory chain complex III (CIII) assembly and stability. Also required for cytochrome c oxidase complex (complex IV) assembly.

References:

[1]. Shan Zhang, et al. Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly. Nat Commun. 2020 Mar 11;11(1):1312. [Content Brief]

[2]. Sven Dennerlein, et al. Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. Elife. 2021 Dec 31;10:e68213. [Content Brief]

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