Protein LSM14 homolog A

Definition:

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.

References:

[1]. Wei-Hong Yang, et al. RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. RNA. 2006 Apr;12(4):547-54. [Content Brief]

[2]. Kimio J Tanaka, et al. RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes. J Biol Chem. 2006 Dec 29;281(52):40096-106. [Content Brief]

[3]. Donia Mili, et al. Localization and role of RAP55/LSM14 in HeLa cells: a new finding on the mitotic spindle assembly. Acta Biochim Pol. 2015;62(3):613-9. [Content Brief]

[4]. Tobias Brandmann, et al. Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes. EMBO J. 2018 Apr 3;37(7):e97869. [Content Brief]

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