Protein max

Definition:

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.

References:

[1]. Iñaki Comino-Méndez, et al. Functional and in silico assessment of MAX variants of unknown significance. J Mol Med (Berl). 2015 Nov;93(11):1247-55. [Content Brief]

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