Protein mono-ADP-ribosyltransferase PARP16

Definition:

Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases.

References:

[1]. Sejal Vyas, et al. Family-wide analysis of poly(ADP-ribose) polymerase activity. Nat Commun. 2014 Jul 21;5:4426. [Content Brief]

[2]. Sridevi Challa, et al. Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Cell. 2021 Aug 19;184(17):4531-4546.e26. [Content Brief]

[3]. Miri Jwa, et al. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response. Nat Cell Biol. 2012 Nov;14(11):1223-30. [Content Brief]

[4]. Simone Di Paola, et al. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1. PLoS One. 2012;7(6):e37352. [Content Brief]

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