Protein NPAT

Definition:

Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.

References:

[1]. J Zhao, et al. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 1998 Feb 15;12(4):456-61. [Content Brief]

[2]. Guang Gao, et al. NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol. 2003 Apr;23(8):2821-33. [Content Brief]

[3]. Aiyan Wang, et al. Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1509-16. [Content Brief]

[4]. Ricardo Medina, et al. The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. Cancer Res. 2007 Nov 1;67(21):10334-42. [Content Brief]

[5]. J Zhao, et al. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 2000 Sep 15;14(18):2283-97. [Content Brief]

[6]. Partha Mitra, et al. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. J Cell Biochem. 2007 May 1;101(1):181-91. [Content Brief]

[7]. Partha Mitra, et al. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. Mol Cell Biol. 2003 Nov;23(22):8110-23. [Content Brief]

[8]. T Ma, et al. Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 2000 Sep 15;14(18):2298-313. [Content Brief]

[9]. Yue Wei, et al. The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain. Mol Cell Biol. 2003 May;23(10):3669-80. [Content Brief]

[10]. Angela Miele, et al. HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition. Mol Cell Biol. 2005 Jul;25(14):6140-53. [Content Brief]

[11]. Xin Ye, et al. The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells. Mol Cell Biol. 2003 Dec;23(23):8586-600. [Content Brief]

[12]. William F Holmes, et al. Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells. J Biol Chem. 2005 Nov 11;280(45):37400-7. [Content Brief]

[13]. Michael DeRan, et al. Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. Mol Cell Biol. 2008 Jan;28(1):435-47. [Content Brief]

[14]. Rong-Lin Xie, et al. Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition. Gene. 2007 Nov 1;402(1-2):94-102. [Content Brief]

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