T-box brain protein 1

Definition:

Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity).

References:

[1]. Pelagia Deriziotis, et al. De novo TBR1 mutations in sporadic autism disrupt protein functions. Nat Commun. 2014 Sep 18;5:4954. [Content Brief]

[2]. Joery den Hoed, et al. Functional characterization of TBR1 variants in neurodevelopmental disorder. Sci Rep. 2018 Sep 24;8(1):14279. [Content Brief]

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