Tapasin

Definition:

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

References:

[1]. Boyoun Park, et al. An essential function of tapasin in quality control of HLA-G molecules. J Biol Chem. 2003 Apr 18;278(16):14337-45. [Content Brief]

[2]. Andreas Blees, et al. Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch. Sci Rep. 2015 Nov 27;5:17341. [Content Brief]

[3]. S Li, et al. Tapasin is required for efficient peptide binding to transporter associated with antigen processing. J Biol Chem. 2000 Jan 21;275(3):1581-6. [Content Brief]

[4]. Syed Monem Rizvi, et al. Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. J Immunol. 2011 Feb 15;186(4):2309-20. [Content Brief]

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