Tectonic-3

Definition:

Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.

References:

[1]. Sophie Thomas, et al. TCTN3 mutations cause Mohr-Majewski syndrome. Am J Hum Genet. 2012 Aug 10;91(2):372-8. [Content Brief]

[2]. Kyung Mi Park, et al. Identification of novel regulators of apoptosis using a high-throughput cell-based screen. Mol Cells. 2007 Apr 30;23(2):170-4. [Content Brief]

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