Transcription factor E2F1

Definition:

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B.

References:

[1]. Craig Stevens, et al. Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol. 2003 May;5(5):401-9. [Content Brief]

[2]. M A Martínez-Balbás, et al. Regulation of E2F1 activity by acetylation. EMBO J. 2000 Feb 15;19(4):662-71. [Content Brief]

[3]. X Wu, et al. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3602-6. [Content Brief]

[4]. Chuangui Wang, et al. Regulation of E2F1 function by the nuclear corepressor KAP1. J Biol Chem. 2007 Oct 12;282(41):29902-9. [Content Brief]

[5]. Jason C Paik, et al. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J Biol Chem. 2010 Feb 26;285(9):6348-63. [Content Brief]

[6]. Katrin Zaragoza, et al. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol Cell Biol. 2010 May;30(9):2293-304. [Content Brief]

[7]. Chaochen Wang, et al. PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma. FEBS Lett. 2008 Aug 6;582(18):2793-8. [Content Brief]

[8]. Gisela García-Alvarez, et al. Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity. Biochim Biophys Acta. 2007 Mar;1773(3):375-82. [Content Brief]

[9]. Dan Wang, et al. Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells. J Mol Cell Biol. 2018 Feb 1;10(1):60-73. [Content Brief]

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