Transmembrane 9 superfamily member 4

Definition:

Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells. Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells.

References:

[1]. Jackie Perrin, et al. TM9 family proteins control surface targeting of glycine-rich transmembrane domains. J Cell Sci. 2015 Jul 1;128(13):2269-77. [Content Brief]

[2]. Francesco Lozupone, et al. The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells. EMBO Rep. 2009 Dec;10(12):1348-54. [Content Brief]

[3]. F Lozupone, et al. TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells. Oncogene. 2015 Oct 1;34(40):5163-74. [Content Brief]

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