Transmembrane emp24 domain-containing protein 1

Definition:

Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.

References:

[1]. Dympna J Connolly, et al. The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling. J Biol Chem. 2013 Feb 22;288(8):5616-23. [Content Brief]

[2]. Emma J Fenech, et al. Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling. Elife. 2020 Jul 2;9:e57306. [Content Brief]

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