Transmembrane protein 45B

Definition:

Plays a role in innate immunity. Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1..

References:

[1]. Feixiang Yan, et al. TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication. J Virol. 2022 Sep 14;96(17):e0091922. [Content Brief]

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