Treslin

Definition:

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.

References:

[1]. Akiko Kumagai, et al. Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. Cell. 2010 Feb 5;140(3):349-59. [Content Brief]

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