Triokinase/FMN cyclase

Definition:

Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.

References:

[1]. E Beutler, et al. Dihydroxyacetone metabolism by human erythrocytes: demonstration of triokinase activity and its characterization. Blood. 1973 Apr;41(4):559-68. [Content Brief]

[2]. Saskia B Wortmann, et al. Bi-allelic Variants in TKFC Encoding Triokinase/FMN Cyclase Are Associated with Cataracts and Multisystem Disease. Am J Hum Genet. 2020 Feb 6;106(2):256-263. [Content Brief]

[3]. Feici Diao, et al. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11706-11. [Content Brief]

[4]. Alicia Cabezas, et al. Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1682-9. [Content Brief]

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