Tubulin--tyrosine ligase-like protein 12

Definition:

Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.

References:

[1]. Lin-Gao Ju, et al. TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS. J Immunol. 2017 Feb 1;198(3):1274-1284. [Content Brief]

[2]. Jan Brants, et al. Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PLoS One. 2012;7(12):e51258. [Content Brief]

[3]. Christine Wasylyk, et al. Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy. Int J Cancer. 2010 Dec 1;127(11):2542-53. [Content Brief]

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