2. Membrane Transporter/Ion Channel
  3. NKCC
  4. Bumetanide-d5

Bumetanide-d5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with  IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

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Bumetanide-d<sub>5</sub> Chemical Structure

Bumetanide-d5 Chemical Structure

CAS No. : 1216739-35-3

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5 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Bumetanide-d5:

Bumetanide-d5 Related Antibodies

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Description

Bumetanide-d5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with  IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

Molecular Weight

369.45

Formula

C17H15D5N2O5S
CAS No.
Unlabeled Cas

28395-03-1
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC(NCCCC)=C(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(S(=O)(N)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 33 mg/mL (89.32 mM)

DMSO : ≥ 25 mg/mL (67.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 14 mg/mL (37.89 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7067 mL 13.5336 mL 27.0673 mL
5 mM 0.5413 mL 2.7067 mL 5.4135 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / DMF 1 mM 2.7067 mL 13.5336 mL 27.0673 mL 67.6682 mL
5 mM 0.5413 mL 2.7067 mL 5.4135 mL 13.5336 mL
10 mM 0.2707 mL 1.3534 mL 2.7067 mL 6.7668 mL
15 mM 0.1804 mL 0.9022 mL 1.8045 mL 4.5112 mL
20 mM 0.1353 mL 0.6767 mL 1.3534 mL 3.3834 mL
25 mM 0.1083 mL 0.5413 mL 1.0827 mL 2.7067 mL
30 mM 0.0902 mL 0.4511 mL 0.9022 mL 2.2556 mL
DMSO / DMF 40 mM 0.0677 mL 0.3383 mL 0.6767 mL 1.6917 mL
50 mM 0.0541 mL 0.2707 mL 0.5413 mL 1.3534 mL
60 mM 0.0451 mL 0.2256 mL 0.4511 mL 1.1278 mL
DMF 80 mM 0.0338 mL 0.1692 mL 0.3383 mL 0.8459 mL
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Bumetanide-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bumetanide-d51216739-35-3NKCCNa-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporterInhibitorinhibitorinhibit

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