CCK antagonist 1

Cat. No.: HY-162070 Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CCK antagonist 1 (compound 3d) is a CCK antagonist with IC₅₀s of 1.1 μM and 4 μM for CCK1 and CCK2, respectively. CCK antagonist 1 can be used for research of cancer and mental disease.

For research use only. We do not sell to patients.

CCK antagonist 1 Chemical Structure

CAS No. : 742116-45-6

Size	Price	Stock	Quantity
5 mg	USD 166	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

CCK antagonist 1 (compound 3d) is a CCK antagonist with IC₅₀s of 1.1 μM and 4 μM for CCK1 and CCK2, respectively. CCK antagonist 1 can be used for research of cancer and mental disease^[1].

IC₅₀ & Target

IC50: 1.1 μM (CCK1), 4 μM (CCK2)^[2]

Molecular Weight

374.44

Formula

C₂₂H₂₂N₄O₂

CAS No.

742116-45-6

Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC1=CNC2=C1C=CC=C2)NC3=C(C)N(C)N(C4=CC=CC=C4)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (333.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6707 mL	13.3533 mL	26.7065 mL
5 mM	0.5341 mL	2.6707 mL	5.3413 mL
10 mM	0.2671 mL	1.3353 mL	2.6707 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (255 KB) HNMR (264 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Eric Lattmann, et al. Novel ureido - and amido-pyrazolone derivatives. Patent WO2004106306A1.

[2]. Lattmann E, et al. Synthesis and evaluation of N-(3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-1H-indole-carboxamides as cholecystokinin antagonists. J Pharm Pharmacol. 2006 Mar;58(3):393-401. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6707 mL	13.3533 mL	26.7065 mL	66.7664 mL
	5 mM	0.5341 mL	2.6707 mL	5.3413 mL	13.3533 mL
	10 mM	0.2671 mL	1.3353 mL	2.6707 mL	6.6766 mL
	15 mM	0.1780 mL	0.8902 mL	1.7804 mL	4.4511 mL
	20 mM	0.1335 mL	0.6677 mL	1.3353 mL	3.3383 mL
	25 mM	0.1068 mL	0.5341 mL	1.0683 mL	2.6707 mL
	30 mM	0.0890 mL	0.4451 mL	0.8902 mL	2.2255 mL
	40 mM	0.0668 mL	0.3338 mL	0.6677 mL	1.6692 mL
	50 mM	0.0534 mL	0.2671 mL	0.5341 mL	1.3353 mL
	60 mM	0.0445 mL	0.2226 mL	0.4451 mL	1.1128 mL
	80 mM	0.0334 mL	0.1669 mL	0.3338 mL	0.8346 mL
	100 mM	0.0267 mL	0.1335 mL	0.2671 mL	0.6677 mL

CCK antagonist 1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCK antagonist 1742116-45-6CCK antagonist1CCK antagonist-1Cholecystokinin ReceptorCCK ReceptorCCK antagonistcancermental diseaseInhibitorinhibitorinhibit

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