2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. CK1α degrader-1

CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC50 of 0.105 μM. CK1α degrader-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

CK1α degrader-1 Chemical Structure

CK1α degrader-1 Chemical Structure

CAS No. : 2881012-96-8

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CK1α degrader-1 Related Antibodies

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Description

CK1α degrader-1 (Compound 82) is an orally active CK1α degrader with a DC50 of 0.105 μM. CK1α degrader-1 can be used for the research of cancer[1].

In Vivo


Pharmacokinetic Analysis in Model[1]

Route Dose (mg/kg) CL (mL/min/kg) C0 (ng/mL) t1/2 (hr) Vss (L/kg)
i.v. 2 10.5 6796 1.34 0.85
Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) AUC(0-inf) (ng·h/mL) F (%)
p.o. 10 6080 0.67 2.03 13264 85

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

466.92

Formula

C24H23ClN4O4
CAS No.
Unlabeled Cas

SMILES

O=C1C2=CC=C(C(N[C@H](C3=CC=C(C=N3)Cl)C4CCC4)=O)C=C2CN1[C@@H]5C(NC(CC5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CK1α degrader-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK1α degrader-12881012-96-8Casein KinaseCK1αcancerorally activeInhibitorinhibitorinhibit

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HY-160532
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