2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor Endogenous Metabolite
  4. Cortisone-d8

Cortisone-d8 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

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Cortisone-d<sub>8</sub> Chemical Structure

Cortisone-d8 Chemical Structure

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1 mg USD 1090 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cortisone-d8:

Cortisone-d8 Related Antibodies

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Description

Cortisone-d8 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cortisone-d8 Related Antibodies
Molecular Weight

368.49

Formula

C21H20D8O5
Unlabeled Cas

53-06-5
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1(C2([2H])[2H])[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CC([2H])([2H])C4=C([2H])C(C([2H])([2H])C[C@]4(C)[C@@]3([2H])C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (271.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7138 mL 13.5689 mL 27.1378 mL
5 mM 0.5428 mL 2.7138 mL 5.4276 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7138 mL 13.5689 mL 27.1378 mL 67.8444 mL
5 mM 0.5428 mL 2.7138 mL 5.4276 mL 13.5689 mL
10 mM 0.2714 mL 1.3569 mL 2.7138 mL 6.7844 mL
15 mM 0.1809 mL 0.9046 mL 1.8092 mL 4.5230 mL
20 mM 0.1357 mL 0.6784 mL 1.3569 mL 3.3922 mL
25 mM 0.1086 mL 0.5428 mL 1.0855 mL 2.7138 mL
30 mM 0.0905 mL 0.4523 mL 0.9046 mL 2.2615 mL
40 mM 0.0678 mL 0.3392 mL 0.6784 mL 1.6961 mL
50 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3569 mL
60 mM 0.0452 mL 0.2261 mL 0.4523 mL 1.1307 mL
80 mM 0.0339 mL 0.1696 mL 0.3392 mL 0.8481 mL
100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6784 mL
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Cortisone-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortisone-d8Glucocorticoid ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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