Crenulatin 

Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity^[1][2][3].

Crenulatin (25 mg/L, 100 mg/L; 24 h) induces apoptosis at 100 mg/L, and inhibits apoptosis at 25 mg/L, in mouse cerebral microvascular endothelial cells (bEnd. 3 cell line), accompanying with caspase-3 expression increases or decrease, respectivley^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

248.27

C₁₁H₂₀O₆

63026-02-8

Solid

White to off-white

CC(C=C)(C)O[C@@H]([C@@H]([C@H]1O)O)O[C@@H]([C@H]1O)CO

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Marchev AS, et al. Authenticity and quality evaluation of different Rhodiola species and commercial products based on NMR-spectroscopy and HPLC. Phytochem Anal. 2020 Nov;31(6):756-769.  [Content Brief]

  [2]. W S Yu, et al. Polyphenols from Rhodiola crenulata. Planta Med. 1993 Feb;59(1):80-2.  [Content Brief]

  [3]. Qian R, et al. Dual-direction effect of crenulatin on apoptosis of cerebral microvascular endothelial cells and it's mechanism[J]. Chinese Journal of Pathophysiology, 2005: 2086-2090.