1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. D-erythro-Sphingosine hydrochloride

D-erythro-Sphingosine hydrochloride  (Synonyms: Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride)

Cat. No.: HY-W089922 Purity: ≥97.0%
COA Handling Instructions

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation.

For research use only. We do not sell to patients.

D-erythro-Sphingosine hydrochloride Chemical Structure

D-erythro-Sphingosine hydrochloride Chemical Structure

CAS No. : 2673-72-5

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Based on 2 publication(s) in Google Scholar

Other Forms of D-erythro-Sphingosine hydrochloride:

Top Publications Citing Use of Products

2 Publications Citing Use of MCE D-erythro-Sphingosine hydrochloride

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation[1][2].

IC50 & Target[1][2]

TRPM3

 

Retinoblastoma protein

 

In Vitro

Extracellular application of D-erythro-Sphingosine (20 μM) induces an increase in [Ca2+]i in TRPM3-transfected HEK293 cells within 20 to 30 s after start of application, whereas nontransfected control cells (NT) shows only very small responses[1].
D-erythro-Sphingosine (10 μM) induces currents through TRPM3[1].
Induction of retinoblastoma protein dephosphorylation by D-erythro-Sphingosine (500 nM; 24 h) precede inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

335.95

Formula

C18H38ClNO2

CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO.[H]Cl

Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

References
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D-erythro-Sphingosine hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
D-erythro-Sphingosine hydrochloride
Cat. No.:
HY-W089922
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